Study of Antiphlogistic Effect of Saussurea lappa Roots’ Ethanol Extract in Comparison to Paracetamol Effect
Amad Abdelkarim El Marghani, Mohammed Abdelfatah Alhoot, Muhd Ridzuan Pauzi, Mahfoudh Abdulghani, Tee Yee Sim, and Khaled Algariri
The current research was designed to investigate the anti-inflammatory action of 100% Saussurea lappa roots’ ethanol extract compared to paracetamol through carrageenan induced hind paw edema model with using of ibuprofen 40 mg/kg as a positive control. Prior to testing, it was important to check the acute toxicity effects of the plant, thus the evaluation test processed by the fixed-dose procedure (FDP). Statistical analysis was attempted to check the mean differences via one-way ANOVA, at that point followed by post-Tukey and Dunnett two-sided tests. The FDP test revealed that extract was safe for additional in-vivo testing, and it was classified as category 5/unclassified on globally harmonized system (GHS) for the classification of chemicals which cause acute toxicity. The extract showed a significant antiphlogistic potential of 15.11% at 500 mg/kg compared to 13.23% of paracetamol 100 mg/kg at P< 0.01. It is assumed that the fundamentally mindful phytoconstituents to share this impact are sesquiterpene lactones (costunolide and dehydrocostus lactone), in which numerous examinations uncovered that these mixtures which found in numerous plants have a powerful anti-inflammatory activity.