MICROSTRUCTURE OF HYDROXYAPATITE SCAFFOLDS: EFFECT OF INFILTRATION METHOD AND POLYURETHANE TEMPLATE PORE SIZE

Muhammad Awaludin MS and Mariattia M*

  • Mariattia M

Abstract

Microstructure of Hydroxyapatite Scaffolds: Effect of Infiltration Method and Polyurethane Template Pore Size

 

Muhammad Awaludin MS and Mariattia M[*]

School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang, Malaysia.

 

Porous ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials. In this study, porous hydroxyapatite (HA) was produced via polymer replication method. Polyurethane (PU) sponge was selected as the template and synthetic binder, polyvinyl alcohol (PVA) was used in this study. Fixed formulation of HA powder, distilled water and PVA (40:60:3) were prepared and stirred at a constant 4 hours time. PU sponges with 30 ppi and 60 ppi size were cut and impregnated in slurry using vacuum and roller infiltration methods. The microstructures were observed by using field emission scanning electron microscope (FESEM). The results obtained indicate that vacuum infiltration method and 60 ppi template pore size exhibited the highest compressive strength with moderate average strut thickness and lowest average pore size compared to samples produced by roller infiltration method at different template pore size.

 

Keywords: porous  hydroxyapatite, polymer replication method, polyurethane

 

 

[*] Corresponding author: E-mail: mariatti@usm.my

Published
2015-12-31
Section
Original Research Articles