LOOKING INTO THE MICROSTRUCTURE OF BIOMATERIALS AND ITS INHABITANTS IN ENGINEERED BONE TISSUE

M.Y. Phang , M.H. Angela Ng, H. Fuzina, B.S. Aminuddin, B.H.I. Ruszymah & O. Fauziah*

  • Fauziah Othman

Abstract

LOOKING INTO THE MICROSTRUCTURE OF BIOMATERIALS AND ITS INHABITANTS IN ENGINEERED BONE TISSUE

M.Y. Phang 1 M.H. Angela Ng2, H. Fuzina 3, B.S. Aminuddin4, B.H.I. Ruszymah5 & O. Fauziah1,6*

1Institute of Bioscience, 6Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 2Tissue Engineering and Human Genetic Lab, 3Institute of Medical Research,4Ear, Nose & Throat Consultation Clinic, Ampang Puteri Specialist Hospital Kuala Lumpur, 'Physiology Department, Universiti Kebangsaan Malaysia.

Bone substitutes are required in the growing-age community, congenital bone deformity, traumatized, tumors or pathological degenerated groups. Autografting procedure often the common practice in orthopedic surgery is still facing some complications. The advent of bone tissue engineering using combination of recipient cells and fabrication of synthetic biomaterial, will hopefully resolve the autograft complication. In this study, osteoprogenitor cells and bone marrow stroma were cultured on tricalcium phosphate (TCPHA) and hydroxyapatite (HA) biomaterials implanted sub-cutaneously in nude mice. SEM observation showed dfferent osteoblast and extracellular morphology between TCPHA and HA biomaterials.

Corresponding author: Tel. +6 (03) 8946 8439; Fax. +6 (03) 8656 7948 E-mail. fauziah@putra.upm.edu.my

Published
2015-12-01
Section
Original Research Articles